Positively charged fluorescent probes thus interact differently with bacterial cell walls from distinct genotypes, which causes conformational changes and different blue/red fluorescence intensity ratios. As genotypically distinct MRSA strains have different levels of PBP2a expression, the content and morphology of negatively charged cell-wall components consequently vary as well. The probes emit either blue fluorescence or red fluorescence depending on their conformation. They synthesized eight fluorescent probes that contained the same core scaffold decorated with diverse pairs of quaternary ammonium salts. developed a sensor array for the identification of different MRSA strains on the basis of changes in fluorescence. Multiple methods are available for the identification of bacterial genotypes by PCR, but they usually require the lysis of bacterial cells and isolation of nucleic acids. MRSA can be categorized into 13 genotypes that differ in their susceptibility to antibiotics, and PBP2a differs between genotypes. Specifically, the mecA gene encodes the penicillin-binding protein PBP2a involved in peptidoglycan biosynthesis, cell-wall formation and resistance to antibiotics. More information, including hours, tours and clickable links to the exhibitors, can be found at /printfair.Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known superbug that has the staphylococcal cassette chromosome mec, a mobile genetic element containing genes that enable resistance to β-lactam antibiotics. 29 with Helen Swift, Japan Foundation Assistant Curator of Asian Art. Tickets are $50, available at /11099a/Portland-Fine-Print-Fair-Benefit-Preview.Įnjoy guided tours with Mary Weaver Chapin, Ph.D., Curator of Prints and Drawings, at 10:30 a.m. The preview is a benefit for the Print Department of the Portland Art Museum. 27, an opportunity to view the fair before it opens to the public. Prints from the Old Masters to contemporary emerging artists will be on sale and excellent works can be found in all price ranges.Īdmission is free on Saturday and Sunday, Jan. Patrons can peruse and purchase prints from 16 top dealers from across North America and Europe. Now in its 10th year, this is the largest and most comprehensive print fair on the West Coast.

27-29 in the Fields Ballroom of the Portland Art Museum, 1219 S.W. The Portland Fine Print Fair returns as an in-person event from Jan.

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